Polymer supports have been increasingly used in recent years for automated organic synthesis and catalysis. Cross-linked polystyrole resins have been used in the form of "microbeads," especially in solid phase chemistry. Some disadvantages of these solid phase supports are their low loading capacity (typically less than 1,5 mmol/g) and the heterogenic reaction conditions when used in organic solvents. Further development of special linker systems is still needed, which makes the production of functionalized carrier resins very expensive. Dendritic polymers, on the other hand, can be directly used as soluble supports with a high loading capacity for organic synthesis. The separation of the soluble polymers from the reaction mixture is based on membrane separation procedures (dialysis or ultrafiltration). Dendritic polyglycerol (PG) has proven to be especially advantageous for its easy accessibility, high chemical stability, and enormous loading capacity of up to 14 mmol/g. (Scheme 1) For example, carbonyl compounds or boronic acids can be directly coupled to the terminals of 1,2-diols of polyglycerols, chemically modified, and subsequently easily cleaved off again. Two goals of our current research are the synthesis of new drugs, e.g., gabapentine analogues as well as the use of reagents and catalysts on dendritic polyglycerol supports. (Schemes 2,3) Furthermore, new kinds of polystyrol-polyglycerol hybrid polymers (PS-PG) are being synthesized and examined for their suitability as high loading solid phase materials.